Drug interactions
Glibenclamide + Methyclothiazide
Severity: Moderate
Glibenclamide and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effectiveness of glyburide, particularly at higher doses. Glycemic control may worsen after a thiazide is started, and thiazide-induced hypokalemia can further impair insulin secretion.
What this interaction means in plain words
Glibenclamide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides cause hypokalemia and insulin resistance, impairing insulin release and opposing sulfonylurea action.
What to do
Monitor blood glucose and serum potassium after starting or changing the thiazide dose. Increase the glyburide dose or adjust therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Methyclothiazide?
MediHelp rates the interaction as moderate. Glibenclamide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effectiveness of glyburide, particularly at higher doses. Glycemic control may worsen after a thiazide is started, and thiazide-induced hypokalemia can further impair insulin secretion.
How serious is the interaction between Glibenclamide and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium after starting or changing the thiazide dose. Increase the glyburide dose or adjust therapy if control worsens.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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