Drug interactions
Glibenclamide + Sacubitril / valsartan
Severity: Minor
Glibenclamide and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide inhibits OATP1B1 and may modestly raise valsartan exposure, but the clinical relevance is unclear. Any effect would be additive hypotension or renal effects. ACE-inhibitor-like agents may also enhance glucose lowering.
What this interaction means in plain words
Glibenclamide and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible OATP1B1 inhibition by glyburide reducing hepatic uptake of valsartan.
What to do
No routine dose change is needed. Monitor blood pressure and renal function as usual and watch for hypoglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Glibenclamide and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glyburide inhibits OATP1B1 and may modestly raise valsartan exposure, but the clinical relevance is unclear. Any effect would be additive hypotension or renal effects. ACE-inhibitor-like agents may also enhance glucose lowering.
How serious is the interaction between Glibenclamide and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor blood pressure and renal function as usual and watch for hypoglycemia.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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