Drug interactions
Glibenclamide + Sage
Severity: Minor
Glibenclamide and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sage preparations have shown blood glucose-lowering activity in some studies, so taking them with glyburide could increase the risk of hypoglycemia. The effect varies with the product and dose consumed.
What this interaction means in plain words
Glibenclamide and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive glucose-lowering effect of sage constituents with sulfonylurea-induced insulin secretion.
What to do
Advise patients to report use of sage supplements and monitor blood glucose for hypoglycemia. Reduce the glyburide dose if low readings occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Sage?
MediHelp rates the interaction as minor. Glibenclamide and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sage preparations have shown blood glucose-lowering activity in some studies, so taking them with glyburide could increase the risk of hypoglycemia. The effect varies with the product and dose consumed.
How serious is the interaction between Glibenclamide and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report use of sage supplements and monitor blood glucose for hypoglycemia. Reduce the glyburide dose if low readings occur.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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