Drug interactions
Glibenclamide + Sofosbuvir / velpatasvir
Severity: Moderate
Glibenclamide and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits BCRP and other transporters, which may increase exposure to glyburide, a substrate. Higher exposure could raise the risk of hypoglycemia. Glucose control can also change as hepatitis C is cleared.
What this interaction means in plain words
Glibenclamide and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Velpatasvir inhibits intestinal BCRP and possibly other transporters, increasing glyburide absorption.
What to do
Monitor blood glucose closely during hepatitis C treatment and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Glibenclamide and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits BCRP and other transporters, which may increase exposure to glyburide, a substrate. Higher exposure could raise the risk of hypoglycemia. Glucose control can also change as hepatitis C is cleared.
How serious is the interaction between Glibenclamide and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during hepatitis C treatment and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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