Drug interactions
Glibenclamide + Willow bark
Severity: Minor
Glibenclamide and Willow bark: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylate. Large salicylate doses can lower blood glucose and may displace sulfonylureas from protein binding, so hypoglycemia is possible with glyburide. At typical supplement doses the effect is probably small.
What this interaction means in plain words
Glibenclamide and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate has intrinsic glucose-lowering activity and may displace glyburide from plasma protein binding.
What to do
Monitor blood glucose if willow bark is used regularly, especially at high doses. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Willow bark?
MediHelp rates the interaction as minor. Glibenclamide and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Willow bark contains salicin, which is converted to salicylate. Large salicylate doses can lower blood glucose and may displace sulfonylureas from protein binding, so hypoglycemia is possible with glyburide. At typical supplement doses the effect is probably small.
How serious is the interaction between Glibenclamide and Willow bark?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if willow bark is used regularly, especially at high doses. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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