Drug interactions
Glimepiride-pioglitazone + Indapamide
Severity: Minor
Glimepiride-pioglitazone and Indapamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide is a thiazide-like diuretic that can slightly raise blood glucose and cause hypokalemia, potentially diminishing the effect of glimepiride and pioglitazone. At low doses the effect is usually small.
What this interaction means in plain words
Glimepiride-pioglitazone and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Indapamide belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism via diuretic-related hypokalemia and impaired insulin secretion.
What to do
Monitor blood glucose and serum potassium, and adjust antidiabetic treatment if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Indapamide
Frequently asked questions
Can I take Glimepiride-pioglitazone with Indapamide?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indapamide is a thiazide-like diuretic that can slightly raise blood glucose and cause hypokalemia, potentially diminishing the effect of glimepiride and pioglitazone. At low doses the effect is usually small.
How serious is the interaction between Glimepiride-pioglitazone and Indapamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium, and adjust antidiabetic treatment if control worsens.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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