Drug interactions
Glimepiride-pioglitazone + Indinavir
Severity: Moderate
Glimepiride-pioglitazone and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir has been associated with insulin resistance and hyperglycemia, which may reduce the efficacy of glimepiride and pioglitazone. New-onset or worsening diabetes has been reported with protease inhibitors.
What this interaction means in plain words
Glimepiride-pioglitazone and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitors impair insulin-mediated glucose uptake (GLUT4 inhibition), causing insulin resistance.
What to do
Monitor blood glucose regularly and increase antidiabetic therapy if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Frequently asked questions
Can I take Glimepiride-pioglitazone with Indinavir?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir has been associated with insulin resistance and hyperglycemia, which may reduce the efficacy of glimepiride and pioglitazone. New-onset or worsening diabetes has been reported with protease inhibitors.
How serious is the interaction between Glimepiride-pioglitazone and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly and increase antidiabetic therapy if hyperglycemia develops.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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