Drug interactions
Glimepiride-pioglitazone + Isoniazid
Severity: Minor
Glimepiride-pioglitazone and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can impair glucose tolerance and has been reported to reduce the effect of sulfonylureas. Glycemic control may worsen during tuberculosis treatment.
What this interaction means in plain words
Glimepiride-pioglitazone and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Isoniazid belongs to Anti Bacterial.
Why it happens
Mechanism not well established; may involve altered carbohydrate metabolism and hepatic effects.
What to do
Monitor blood glucose during isoniazid therapy and adjust glimepiride dosing if hyperglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Isoniazid
Frequently asked questions
Can I take Glimepiride-pioglitazone with Isoniazid?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid can impair glucose tolerance and has been reported to reduce the effect of sulfonylureas. Glycemic control may worsen during tuberculosis treatment.
How serious is the interaction between Glimepiride-pioglitazone and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during isoniazid therapy and adjust glimepiride dosing if hyperglycemia develops.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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