Drug interactions
Glimepiride-pioglitazone + Ketorolac
Severity: Moderate
Glimepiride-pioglitazone and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac may enhance the hypoglycemic effect of glimepiride in some patients. It can also cause fluid retention and reduce renal function, which matters in patients taking pioglitazone.
What this interaction means in plain words
Glimepiride-pioglitazone and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Ketorolac belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement and prostaglandin inhibition affecting glucose handling and renal function; mechanism not firmly established.
What to do
Monitor blood glucose during co-administration and keep ketorolac courses short. Check renal function and watch for edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Ketorolac?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac may enhance the hypoglycemic effect of glimepiride in some patients. It can also cause fluid retention and reduce renal function, which matters in patients taking pioglitazone.
How serious is the interaction between Glimepiride-pioglitazone and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during co-administration and keep ketorolac courses short. Check renal function and watch for edema.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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