Drug interactions
Glimepiride-pioglitazone + Lumacaftor / ivacaftor
Severity: Moderate
Glimepiride-pioglitazone and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and may induce CYP2C9, potentially lowering glimepiride and pioglitazone concentrations. Glycemic control may deteriorate.
What this interaction means in plain words
Glimepiride-pioglitazone and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP2C9 and CYP3A4, increasing clearance of glimepiride and pioglitazone.
What to do
Monitor blood glucose after starting lumacaftor/ivacaftor. Increase antidiabetic doses if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Frequently asked questions
Can I take Glimepiride-pioglitazone with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and may induce CYP2C9, potentially lowering glimepiride and pioglitazone concentrations. Glycemic control may deteriorate.
How serious is the interaction between Glimepiride-pioglitazone and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting lumacaftor/ivacaftor. Increase antidiabetic doses if control is lost.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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