Drug interactions
Glimepiride-pioglitazone + Metronidazole
Severity: Minor
Glimepiride-pioglitazone and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole is a weak CYP inhibitor and might slightly raise pioglitazone concentrations. Clinically important effects are unlikely.
What this interaction means in plain words
Glimepiride-pioglitazone and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Metronidazole belongs to Anti Parasitic.
Why it happens
Weak inhibition of CYP-mediated pioglitazone metabolism by metronidazole.
What to do
No dose adjustment is usually required; monitor for hypoglycemia and edema during prolonged courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Metronidazole?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole is a weak CYP inhibitor and might slightly raise pioglitazone concentrations. Clinically important effects are unlikely.
How serious is the interaction between Glimepiride-pioglitazone and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for hypoglycemia and edema during prolonged courses.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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