Drug interactions
Glimepiride-pioglitazone + Mipomersen
Severity: Moderate
Glimepiride-pioglitazone and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen commonly raises liver transaminases and causes hepatic steatosis. Glimepiride and pioglitazone also carry hepatic safety concerns, so the combined effect may add to liver injury risk.
What this interaction means in plain words
Glimepiride-pioglitazone and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxicity; no pharmacokinetic interaction is established.
What to do
Check liver enzymes at baseline and regularly during combined therapy. Stop the offending drug if transaminases rise significantly or liver injury is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Frequently asked questions
Can I take Glimepiride-pioglitazone with Mipomersen?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen commonly raises liver transaminases and causes hepatic steatosis. Glimepiride and pioglitazone also carry hepatic safety concerns, so the combined effect may add to liver injury risk.
How serious is the interaction between Glimepiride-pioglitazone and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver enzymes at baseline and regularly during combined therapy. Stop the offending drug if transaminases rise significantly or liver injury is suspected.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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