Drug interactions
Glimepiride-pioglitazone + Nefazodone
Severity: Minor
Glimepiride-pioglitazone and Nefazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and may modestly increase pioglitazone exposure, which is metabolized mainly by CYP2C8 with some CYP3A4 contribution. This could increase fluid retention or edema and hypoglycemia risk with the combination product.
What this interaction means in plain words
Glimepiride-pioglitazone and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nefazodone inhibits CYP3A4, which has a minor role in pioglitazone metabolism.
What to do
Monitor blood glucose and signs of edema when nefazodone is started or stopped. No routine dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Frequently asked questions
Can I take Glimepiride-pioglitazone with Nefazodone?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nefazodone is a strong CYP3A4 inhibitor and may modestly increase pioglitazone exposure, which is metabolized mainly by CYP2C8 with some CYP3A4 contribution. This could increase fluid retention or edema and hypoglycemia risk with the combination product.
How serious is the interaction between Glimepiride-pioglitazone and Nefazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and signs of edema when nefazodone is started or stopped. No routine dose change is usually needed.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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