Drug interactions
Glimepiride-pioglitazone + Oxymetholone
Severity: Moderate
Glimepiride-pioglitazone and Oxymetholone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymetholone is an anabolic steroid that can lower blood glucose and increase insulin sensitivity. It may enhance the effect of glimepiride and pioglitazone, with a risk of hypoglycemia.
What this interaction means in plain words
Glimepiride-pioglitazone and Oxymetholone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose-lowering effect through increased insulin sensitivity.
What to do
Monitor blood glucose frequently when oxymetholone is started or stopped and reduce the glimepiride dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Frequently asked questions
Can I take Glimepiride-pioglitazone with Oxymetholone?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Oxymetholone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxymetholone is an anabolic steroid that can lower blood glucose and increase insulin sensitivity. It may enhance the effect of glimepiride and pioglitazone, with a risk of hypoglycemia.
How serious is the interaction between Glimepiride-pioglitazone and Oxymetholone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when oxymetholone is started or stopped and reduce the glimepiride dose if needed.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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