Drug interactions
Glimepiride-pioglitazone + Pitavastatin
Severity: Minor
Glimepiride-pioglitazone and Pitavastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The legacy concern is that pioglitazone raises pitavastatin exposure through OATP1B1 inhibition and increases myopathy risk. Pioglitazone is not an established clinically relevant OATP1B1 inhibitor, and no meaningful interaction is documented.
What this interaction means in plain words
Glimepiride-pioglitazone and Pitavastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Pitavastatin belongs to Cardiovascular.
Why it happens
Theoretical OATP1B1 inhibition by pioglitazone; not established clinically.
What to do
No dose adjustment is needed; counsel patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
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- Erythromycin lactobionate + Pitavastatin Major
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Frequently asked questions
Can I take Glimepiride-pioglitazone with Pitavastatin?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Pitavastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The legacy concern is that pioglitazone raises pitavastatin exposure through OATP1B1 inhibition and increases myopathy risk. Pioglitazone is not an established clinically relevant OATP1B1 inhibitor, and no meaningful interaction is documented.
How serious is the interaction between Glimepiride-pioglitazone and Pitavastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; counsel patients to report unexplained muscle pain or weakness.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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