Drug interactions
Glimepiride-pioglitazone + Quinupristin / dalfopristin
Severity: Minor
Glimepiride-pioglitazone and Quinupristin / dalfopristin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise concentrations of drugs partly metabolized by it, including pioglitazone. The clinical effect is probably small because pioglitazone is mainly cleared by CYP2C8.
What this interaction means in plain words
Glimepiride-pioglitazone and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated metabolism of pioglitazone.
What to do
Monitor for edema and hypoglycemia during the short antibiotic course and adjust therapy if signs appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Frequently asked questions
Can I take Glimepiride-pioglitazone with Quinupristin / dalfopristin?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4 and may raise concentrations of drugs partly metabolized by it, including pioglitazone. The clinical effect is probably small because pioglitazone is mainly cleared by CYP2C8.
How serious is the interaction between Glimepiride-pioglitazone and Quinupristin / dalfopristin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for edema and hypoglycemia during the short antibiotic course and adjust therapy if signs appear.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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