Drug interactions
Glimepiride-pioglitazone + Sage
Severity: Minor
Glimepiride-pioglitazone and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sage has shown glucose-lowering effects in animal and small human studies. Taken with glimepiride and pioglitazone, it may add to the glucose-lowering effect and increase the risk of hypoglycemia.
What this interaction means in plain words
Glimepiride-pioglitazone and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hypoglycemic effect; the mechanism of sage is not well established.
What to do
Monitor blood glucose in patients using sage medicinally and reduce glimepiride if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Frequently asked questions
Can I take Glimepiride-pioglitazone with Sage?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sage has shown glucose-lowering effects in animal and small human studies. Taken with glimepiride and pioglitazone, it may add to the glucose-lowering effect and increase the risk of hypoglycemia.
How serious is the interaction between Glimepiride-pioglitazone and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose in patients using sage medicinally and reduce glimepiride if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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