Drug interactions
Gliquidone + Hydrocortisone
Severity: Moderate
Gliquidone and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone raises blood glucose and can reduce the glucose-lowering effect of sulfonylureas such as gliquidone. Glycemic control may worsen, particularly with higher or prolonged steroid doses.
What this interaction means in plain words
Gliquidone and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic glucose production oppose sulfonylurea action.
What to do
Monitor blood glucose more frequently during steroid therapy and increase the antidiabetic dose if needed. Reduce the dose again when the corticosteroid is tapered to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Gliquidone with Hydrocortisone?
MediHelp rates the interaction as moderate. Gliquidone and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrocortisone raises blood glucose and can reduce the glucose-lowering effect of sulfonylureas such as gliquidone. Glycemic control may worsen, particularly with higher or prolonged steroid doses.
How serious is the interaction between Gliquidone and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently during steroid therapy and increase the antidiabetic dose if needed. Reduce the dose again when the corticosteroid is tapered to avoid hypoglycemia.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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