Drug interactions
Glucagon intranasal + Insulin aspart-insulin aspart protamine
Severity: Minor
Glucagon intranasal and Insulin aspart-insulin aspart protamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose and opposes insulin action. This is the intended effect when treating severe hypoglycemia, but it temporarily reduces insulin effect and may cause subsequent hyperglycemia.
What this interaction means in plain words
Glucagon intranasal and Insulin aspart-insulin aspart protamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism: glucagon stimulates hepatic glycogenolysis and gluconeogenesis.
What to do
After glucagon use for hypoglycemia, give oral carbohydrate once able and monitor blood glucose to guide the next insulin dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Frequently asked questions
Can I take Glucagon intranasal with Insulin aspart-insulin aspart protamine?
MediHelp rates the interaction as minor. Glucagon intranasal and Insulin aspart-insulin aspart protamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon raises blood glucose and opposes insulin action. This is the intended effect when treating severe hypoglycemia, but it temporarily reduces insulin effect and may cause subsequent hyperglycemia.
How serious is the interaction between Glucagon intranasal and Insulin aspart-insulin aspart protamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: After glucagon use for hypoglycemia, give oral carbohydrate once able and monitor blood glucose to guide the next insulin dose.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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