Drug interactions
Glucagon intranasal + Insulin aspart
Severity: Minor
Glucagon intranasal and Insulin aspart: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose and directly opposes insulin. This is the intended effect when treating severe hypoglycemia but can cause transient hyperglycemia afterwards.
What this interaction means in plain words
Glucagon intranasal and Insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glucagon stimulates hepatic glycogenolysis and gluconeogenesis, which opposes insulin.
What to do
Use for severe hypoglycemia as intended, then give oral carbohydrate and monitor glucose. Review the insulin dose to prevent a recurrence.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin aspart
Frequently asked questions
Can I take Glucagon intranasal with Insulin aspart?
MediHelp rates the interaction as minor. Glucagon intranasal and Insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon raises blood glucose and directly opposes insulin. This is the intended effect when treating severe hypoglycemia but can cause transient hyperglycemia afterwards.
How serious is the interaction between Glucagon intranasal and Insulin aspart?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use for severe hypoglycemia as intended, then give oral carbohydrate and monitor glucose. Review the insulin dose to prevent a recurrence.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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