Drug interactions
Glucagon intranasal + Insulin neutral human-insulin isophane protamine human
Severity: Minor
Glucagon intranasal and Insulin neutral human-insulin isophane protamine human: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose and opposes insulin action. This is the intended effect when treating severe hypoglycemia, but it temporarily reduces insulin effect and may cause subsequent hyperglycemia.
What this interaction means in plain words
Glucagon intranasal and Insulin neutral human-insulin isophane protamine human have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism: glucagon stimulates hepatic glycogenolysis and gluconeogenesis.
What to do
After glucagon use for hypoglycemia, give oral carbohydrate once able and monitor blood glucose to guide the next insulin dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Frequently asked questions
Can I take Glucagon intranasal with Insulin neutral human-insulin isophane protamine human?
MediHelp rates the interaction as minor. Glucagon intranasal and Insulin neutral human-insulin isophane protamine human have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon raises blood glucose and opposes insulin action. This is the intended effect when treating severe hypoglycemia, but it temporarily reduces insulin effect and may cause subsequent hyperglycemia.
How serious is the interaction between Glucagon intranasal and Insulin neutral human-insulin isophane protamine human?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: After glucagon use for hypoglycemia, give oral carbohydrate once able and monitor blood glucose to guide the next insulin dose.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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