Drug interactions
Glucagon intranasal + Propranolol
Severity: Minor
Glucagon intranasal and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon triggers catecholamine release that can transiently raise heart rate and blood pressure, an effect that may be exaggerated with non-selective beta blockade through unopposed alpha stimulation. Its glucose-raising action may also be less predictable.
What this interaction means in plain words
Glucagon intranasal and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Beta blockade alters the cardiovascular response to glucagon-induced catecholamine release.
What to do
Monitor blood pressure, heart rate and glucose after glucagon administration. Treat persistent hypoglycemia with oral or intravenous glucose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Glucagon intranasal with Propranolol?
MediHelp rates the interaction as minor. Glucagon intranasal and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon triggers catecholamine release that can transiently raise heart rate and blood pressure, an effect that may be exaggerated with non-selective beta blockade through unopposed alpha stimulation. Its glucose-raising action may also be less predictable.
How serious is the interaction between Glucagon intranasal and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and glucose after glucagon administration. Treat persistent hypoglycemia with oral or intravenous glucose.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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