Drug interactions
Glucagon intranasal + Trihexyphenidyl
Severity: Moderate
Glucagon intranasal and Trihexyphenidyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both anticholinergics and glucagon reduce gastrointestinal motility. Used together they may increase constipation, ileus or other GI adverse effects.
What this interaction means in plain words
Glucagon intranasal and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of gastrointestinal motility.
What to do
Monitor for abdominal distension, constipation and reduced bowel sounds after glucagon dosing. Glucagon is typically a single emergency dose, so no pre-emptive change is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trihexyphenidyl
Frequently asked questions
Can I take Glucagon intranasal with Trihexyphenidyl?
MediHelp rates the interaction as moderate. Glucagon intranasal and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both anticholinergics and glucagon reduce gastrointestinal motility. Used together they may increase constipation, ileus or other GI adverse effects.
How serious is the interaction between Glucagon intranasal and Trihexyphenidyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal distension, constipation and reduced bowel sounds after glucagon dosing. Glucagon is typically a single emergency dose, so no pre-emptive change is required.
What other medicines interact with Trihexyphenidyl?
MediHelp also lists interactions of Trihexyphenidyl with, for example, Orphenadrin, Oxybutynin, Scopolamine. The full list is on the Trihexyphenidyl page.
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