Drug interactions
Gold sodium thiomalate + Perindopril
Severity: Moderate
Gold sodium thiomalate and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Injectable gold has been reported with ACE inhibitors to cause a nitritoid reaction, with flushing, nausea, vomiting and hypotension. The reaction is uncommon but can be distressing and may recur with later injections.
What this interaction means in plain words
Gold sodium thiomalate and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism is not established; it may involve vasodilatory effects potentiated by ACE inhibition.
What to do
Monitor patients for flushing and hypotension after injections, particularly early in therapy. If reactions recur, consider stopping the ACE inhibitor or choosing an alternative antihypertensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gold sodium thiomalate and Perindopril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Gold sodium thiomalate with Perindopril?
MediHelp rates the interaction as moderate. Gold sodium thiomalate and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Injectable gold has been reported with ACE inhibitors to cause a nitritoid reaction, with flushing, nausea, vomiting and hypotension. The reaction is uncommon but can be distressing and may recur with later injections.
How serious is the interaction between Gold sodium thiomalate and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients for flushing and hypotension after injections, particularly early in therapy. If reactions recur, consider stopping the ACE inhibitor or choosing an alternative antihypertensive.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
