Drug interactions
Gold sodium thiomalate + Tofacitinib
Severity: Major
Gold sodium thiomalate and Tofacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gold salts have immunomodulatory effects and can cause bone marrow suppression. Combined with tofacitinib they may increase the risk of infection and cytopenias.
What this interaction means in plain words
Gold sodium thiomalate and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression, with potential additive hematologic toxicity.
What to do
Avoid the combination and use another DMARD strategy where possible. If combined, monitor complete blood counts and signs of infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Frequently asked questions
Can I take Gold sodium thiomalate with Tofacitinib?
MediHelp rates the interaction as major. Gold sodium thiomalate and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gold salts have immunomodulatory effects and can cause bone marrow suppression. Combined with tofacitinib they may increase the risk of infection and cytopenias.
How serious is the interaction between Gold sodium thiomalate and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use another DMARD strategy where possible. If combined, monitor complete blood counts and signs of infection.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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