Drug interactions
Griseofulvin + Hydrocortisone
Severity: Moderate
Griseofulvin and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a CYP3A4 inducer and may lower hydrocortisone exposure, reducing corticosteroid effect. This matters most in adrenal insufficiency, where under-replacement can cause symptoms or adrenal crisis.
What this interaction means in plain words
Griseofulvin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Hydrocortisone belongs to Endocrine.
Why it happens
Induction of CYP3A4-mediated hydrocortisone metabolism by griseofulvin.
What to do
Monitor clinical response and consider increasing hydrocortisone dose in patients on replacement therapy; watch for symptoms of under-replacement.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Hydrocortisone?
MediHelp rates the interaction as moderate. Griseofulvin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin is a CYP3A4 inducer and may lower hydrocortisone exposure, reducing corticosteroid effect. This matters most in adrenal insufficiency, where under-replacement can cause symptoms or adrenal crisis.
How serious is the interaction between Griseofulvin and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider increasing hydrocortisone dose in patients on replacement therapy; watch for symptoms of under-replacement.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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