Drug interactions
Griseofulvin + Indinavir
Severity: Moderate
Griseofulvin and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir depends heavily on CYP3A4 for clearance, so induction by griseofulvin may lower its concentrations. Sub-therapeutic levels risk virologic failure and resistance.
What this interaction means in plain words
Griseofulvin and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Griseofulvin induces CYP3A4, increasing indinavir metabolism.
What to do
Monitor HIV viral load and consider therapeutic drug monitoring of indinavir. Use an alternative antifungal if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Indinavir?
MediHelp rates the interaction as moderate. Griseofulvin and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir depends heavily on CYP3A4 for clearance, so induction by griseofulvin may lower its concentrations. Sub-therapeutic levels risk virologic failure and resistance.
How serious is the interaction between Griseofulvin and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider therapeutic drug monitoring of indinavir. Use an alternative antifungal if feasible.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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