Drug interactions
Griseofulvin + Isradipine
Severity: Minor
Griseofulvin and Isradipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isradipine is a CYP3A4 substrate, so induction may lower its levels and weaken blood pressure control. Griseofulvin is a weak inducer, so the effect is probably small.
What this interaction means in plain words
Griseofulvin and Isradipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 induction by griseofulvin increases isradipine metabolism.
What to do
Monitor blood pressure when griseofulvin is started or stopped, and titrate isradipine to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Isradipine?
MediHelp rates the interaction as minor. Griseofulvin and Isradipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isradipine is a CYP3A4 substrate, so induction may lower its levels and weaken blood pressure control. Griseofulvin is a weak inducer, so the effect is probably small.
How serious is the interaction between Griseofulvin and Isradipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when griseofulvin is started or stopped, and titrate isradipine to response.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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