Drug interactions
Griseofulvin + Sildenafil
Severity: Minor
Griseofulvin and Sildenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a weak CYP3A4 inducer and may modestly reduce sildenafil exposure. Clinical impact is likely small.
What this interaction means in plain words
Griseofulvin and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Sildenafil belongs to Genitourinary.
Why it happens
Griseofulvin induces CYP3A4, increasing sildenafil clearance.
What to do
No routine dose change; monitor for reduced sildenafil response during prolonged griseofulvin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Sildenafil?
MediHelp rates the interaction as minor. Griseofulvin and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is a weak CYP3A4 inducer and may modestly reduce sildenafil exposure. Clinical impact is likely small.
How serious is the interaction between Griseofulvin and Sildenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for reduced sildenafil response during prolonged griseofulvin therapy.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
Full monographs, dosing and an interaction checker in the MediHelp app
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