Drug interactions
Griseofulvin + Zolpidem
Severity: Minor
Griseofulvin and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may reduce zolpidem exposure through weak CYP3A4 induction, since zolpidem is largely metabolized by CYP3A4. Any loss of hypnotic effect is likely modest.
What this interaction means in plain words
Griseofulvin and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Zolpidem belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by griseofulvin may increase zolpidem metabolism.
What to do
No routine adjustment is required; reassess hypnotic efficacy if sleep response declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Other interactions of Zolpidem
Frequently asked questions
Can I take Griseofulvin with Zolpidem?
MediHelp rates the interaction as minor. Griseofulvin and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin may reduce zolpidem exposure through weak CYP3A4 induction, since zolpidem is largely metabolized by CYP3A4. Any loss of hypnotic effect is likely modest.
How serious is the interaction between Griseofulvin and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; reassess hypnotic efficacy if sleep response declines.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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