Drug interactions
Haemophilus influenzae type b vaccine + Hydrocortisone
Severity: Moderate
Haemophilus influenzae type b vaccine and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressive doses of corticosteroids may reduce antibody response to the Hib vaccine. The vaccine is inactivated so it is safe, but protection may be suboptimal.
What this interaction means in plain words
Haemophilus influenzae type b vaccine and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid-induced immunosuppression reduces vaccine immune response.
What to do
Give the vaccine before starting high-dose corticosteroids when feasible. Consider revaccination after immune function recovers if given during immunosuppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Haemophilus influenzae type b vaccine with Hydrocortisone?
MediHelp rates the interaction as moderate. Haemophilus influenzae type b vaccine and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppressive doses of corticosteroids may reduce antibody response to the Hib vaccine. The vaccine is inactivated so it is safe, but protection may be suboptimal.
How serious is the interaction between Haemophilus influenzae type b vaccine and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine before starting high-dose corticosteroids when feasible. Consider revaccination after immune function recovers if given during immunosuppression.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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