Drug interactions
Haemophilus influenzae type b vaccine + Methotrexate
Severity: Moderate
Haemophilus influenzae type b vaccine and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate can reduce the antibody response to Hib conjugate vaccine, so protection may be suboptimal. The vaccine is non-live and safe to give.
What this interaction means in plain words
Haemophilus influenzae type b vaccine and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Methotrexate immunosuppression impairs antigen-specific antibody production.
What to do
Vaccinate at least 2 weeks before methotrexate when possible. If given during therapy, consider revaccination after immune recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Haemophilus influenzae type b vaccine with Methotrexate?
MediHelp rates the interaction as moderate. Haemophilus influenzae type b vaccine and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methotrexate can reduce the antibody response to Hib conjugate vaccine, so protection may be suboptimal. The vaccine is non-live and safe to give.
How serious is the interaction between Haemophilus influenzae type b vaccine and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before methotrexate when possible. If given during therapy, consider revaccination after immune recovery.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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