Drug interactions
Henbane + Olanzapine
Severity: Moderate
Henbane and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids, and these add to the anticholinergic effects of olanzapine. This can cause confusion, constipation, urinary retention, tachycardia and overheating.
What this interaction means in plain words
Henbane and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects of belladonna alkaloids and olanzapine.
What to do
Avoid the combination where possible, or monitor for anticholinergic toxicity including delirium and urinary retention. Counsel patients against using herbal products containing henbane.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Henbane with Olanzapine?
MediHelp rates the interaction as moderate. Henbane and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids, and these add to the anticholinergic effects of olanzapine. This can cause confusion, constipation, urinary retention, tachycardia and overheating.
How serious is the interaction between Henbane and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor for anticholinergic toxicity including delirium and urinary retention. Counsel patients against using herbal products containing henbane.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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