Drug interactions
Heparin + Meclofenamate
Severity: Moderate
Heparin and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate is an NSAID that reduces platelet aggregation and can cause gastrointestinal ulceration. Together with heparin it increases the likelihood of bleeding, especially from the GI tract.
What this interaction means in plain words
Heparin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effect of NSAID-induced platelet COX inhibition and GI mucosal damage with heparin anticoagulation.
What to do
Prefer acetaminophen or another non-NSAID analgesic during heparin therapy. If an NSAID is needed, use the lowest dose for the shortest time and monitor for bleeding signs and hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Heparin with Meclofenamate?
MediHelp rates the interaction as moderate. Heparin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate is an NSAID that reduces platelet aggregation and can cause gastrointestinal ulceration. Together with heparin it increases the likelihood of bleeding, especially from the GI tract.
How serious is the interaction between Heparin and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer acetaminophen or another non-NSAID analgesic during heparin therapy. If an NSAID is needed, use the lowest dose for the shortest time and monitor for bleeding signs and hemoglobin.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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