Drug interactions
Heparin + Mipomersen
Severity: Minor
Heparin and Mipomersen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can cause elevations in hepatic transaminases and hepatic steatosis. Heparin can also raise transaminases modestly, so combined use may make liver enzyme changes harder to interpret.
What this interaction means in plain words
Heparin and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Both agents can independently raise liver enzymes, giving additive effects on laboratory markers of hepatic injury.
What to do
Monitor ALT, AST and bilirubin per mipomersen labeling while heparin is used. Interpret transaminase rises with both drugs in mind.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Heparin with Mipomersen?
MediHelp rates the interaction as minor. Heparin and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mipomersen can cause elevations in hepatic transaminases and hepatic steatosis. Heparin can also raise transaminases modestly, so combined use may make liver enzyme changes harder to interpret.
How serious is the interaction between Heparin and Mipomersen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin per mipomersen labeling while heparin is used. Interpret transaminase rises with both drugs in mind.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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