Drug interactions
Heparin + Perindopril
Severity: Moderate
Heparin and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress adrenal aldosterone production, and ACE inhibitors also lower aldosterone, so hyperkalemia may develop. The risk is higher in diabetes, renal impairment or prolonged heparin use.
What this interaction means in plain words
Heparin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Heparin belongs to Cardiovascular; Perindopril belongs to Cardiovascular.
Why it happens
Additive suppression of aldosterone leading to decreased renal potassium excretion.
What to do
Monitor serum potassium and renal function, particularly when heparin continues beyond several days or in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Heparin with Perindopril?
MediHelp rates the interaction as moderate. Heparin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress adrenal aldosterone production, and ACE inhibitors also lower aldosterone, so hyperkalemia may develop. The risk is higher in diabetes, renal impairment or prolonged heparin use.
How serious is the interaction between Heparin and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, particularly when heparin continues beyond several days or in high-risk patients.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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