Drug interactions
Heparin + Quinapril
Severity: Moderate
Heparin and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise serum potassium, heparin by reducing aldosterone secretion and quinapril by blocking angiotensin II formation. Hyperkalemia risk is greater with renal impairment, diabetes, or prolonged heparin use.
What this interaction means in plain words
Heparin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive suppression of aldosterone-mediated potassium excretion by heparin and ACE inhibition.
What to do
Check serum potassium and creatinine at baseline and periodically during combined use, particularly beyond several days of heparin. Treat hyperkalemia or review therapy if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Heparin and Quinapril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Heparin with Quinapril?
MediHelp rates the interaction as moderate. Heparin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise serum potassium, heparin by reducing aldosterone secretion and quinapril by blocking angiotensin II formation. Hyperkalemia risk is greater with renal impairment, diabetes, or prolonged heparin use.
How serious is the interaction between Heparin and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine at baseline and periodically during combined use, particularly beyond several days of heparin. Treat hyperkalemia or review therapy if potassium rises.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
