Drug interactions
Heparin + Sacubitril / valsartan
Severity: Moderate
Heparin and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress aldosterone secretion, and valsartan blocks angiotensin II receptors, so both lower aldosterone effect on the kidney. This may cause clinically significant hyperkalemia, particularly in renal impairment.
What this interaction means in plain words
Heparin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive reduction of aldosterone-driven renal potassium excretion.
What to do
Monitor serum potassium and renal function during combined use, especially with prolonged heparin therapy. Adjust therapy if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Heparin with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Heparin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress aldosterone secretion, and valsartan blocks angiotensin II receptors, so both lower aldosterone effect on the kidney. This may cause clinically significant hyperkalemia, particularly in renal impairment.
How serious is the interaction between Heparin and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function during combined use, especially with prolonged heparin therapy. Adjust therapy if hyperkalemia develops.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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