Drug interactions
Heparin + Sulfasalazine
Severity: Minor
Heparin and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine can rarely cause blood dyscrasias such as thrombocytopenia and agranulocytosis, which could increase bleeding risk during heparin therapy. A direct pharmacologic interaction is not established.
What this interaction means in plain words
Heparin and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established direct interaction; theoretical additive bleeding risk if sulfasalazine induces cytopenias.
What to do
Monitor complete blood count including platelets, especially as heparin itself can cause thrombocytopenia. Investigate promptly any fall in platelets or bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Heparin with Sulfasalazine?
MediHelp rates the interaction as minor. Heparin and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine can rarely cause blood dyscrasias such as thrombocytopenia and agranulocytosis, which could increase bleeding risk during heparin therapy. A direct pharmacologic interaction is not established.
How serious is the interaction between Heparin and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood count including platelets, especially as heparin itself can cause thrombocytopenia. Investigate promptly any fall in platelets or bleeding.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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