Drug interactions
Heparin + Vorapaxar
Severity: Major
Heparin and Vorapaxar: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is a PAR-1 platelet antagonist that increases bleeding risk. Combined with heparin the risk of significant bleeding rises further, and vorapaxar is contraindicated in patients with prior stroke, TIA or intracranial hemorrhage.
What this interaction means in plain words
Heparin and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment: platelet thrombin-receptor inhibition plus heparin-mediated antithrombin potentiation.
What to do
Monitor closely for bleeding and check hemoglobin and coagulation parameters. Reassess the need for vorapaxar when full-dose anticoagulation is required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Heparin with Vorapaxar?
MediHelp rates the interaction as major. Heparin and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorapaxar is a PAR-1 platelet antagonist that increases bleeding risk. Combined with heparin the risk of significant bleeding rises further, and vorapaxar is contraindicated in patients with prior stroke, TIA or intracranial hemorrhage.
How serious is the interaction between Heparin and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bleeding and check hemoglobin and coagulation parameters. Reassess the need for vorapaxar when full-dose anticoagulation is required.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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