Drug interactions
Hepatitis a / b vaccine + Mercaptopurine
Severity: Minor
Hepatitis a / b vaccine and Mercaptopurine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mercaptopurine can lower antibody responses to this inactivated vaccine, so protection may be incomplete. There is no risk of vaccine-strain infection.
What this interaction means in plain words
Hepatitis a / b vaccine and Mercaptopurine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Immunosuppression reduces the B- and T-cell response to vaccine antigens.
What to do
Vaccinate as scheduled and check anti-HBs and anti-HAV titres afterwards. Revaccinate or give a higher dose if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicated
- Azathioprine + Mercaptopurine Contraindicated
- Bcg vaccine live + Mercaptopurine Contraindicated
- Febuxostat + Mercaptopurine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicated
- Mercaptopurine + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Hepatitis a / b vaccine with Mercaptopurine?
MediHelp rates the interaction as minor. Hepatitis a / b vaccine and Mercaptopurine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mercaptopurine can lower antibody responses to this inactivated vaccine, so protection may be incomplete. There is no risk of vaccine-strain infection.
How serious is the interaction between Hepatitis a / b vaccine and Mercaptopurine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as scheduled and check anti-HBs and anti-HAV titres afterwards. Revaccinate or give a higher dose if the response is inadequate.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
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