Drug interactions
Hepatitis A vaccine inactivated + Mercaptopurine
Severity: Minor
Hepatitis A vaccine inactivated and Mercaptopurine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression from mercaptopurine can blunt the antibody response to inactivated hepatitis A vaccine, leaving the patient less protected. The vaccine is not live, so there is no infection risk from it.
What this interaction means in plain words
Hepatitis A vaccine inactivated and Mercaptopurine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hepatitis A vaccine inactivated belongs to Anti Virals; Mercaptopurine belongs to Oncology.
Why it happens
Pharmacodynamic antagonism: lymphocyte suppression reduces vaccine-induced antibody production.
What to do
Vaccinate as indicated and do not delay needed vaccination. Consider checking antibody titers afterward and giving a further dose if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicated
- Azathioprine + Mercaptopurine Contraindicated
- Bcg vaccine live + Mercaptopurine Contraindicated
- Febuxostat + Mercaptopurine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicated
- Mercaptopurine + Smallpox vaccine live Contraindicated
Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Frequently asked questions
Can I take Hepatitis A vaccine inactivated with Mercaptopurine?
MediHelp rates the interaction as minor. Hepatitis A vaccine inactivated and Mercaptopurine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Immunosuppression from mercaptopurine can blunt the antibody response to inactivated hepatitis A vaccine, leaving the patient less protected. The vaccine is not live, so there is no infection risk from it.
How serious is the interaction between Hepatitis A vaccine inactivated and Mercaptopurine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as indicated and do not delay needed vaccination. Consider checking antibody titers afterward and giving a further dose if response is inadequate.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
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