Drug interactions
Hepatitis A vaccine inactivated + Methotrexate
Severity: Moderate
Hepatitis A vaccine inactivated and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate can blunt antibody responses to vaccines, so protection from hepatitis A vaccination may be reduced. The inactivated vaccine is safe to give, but may need attention to timing or antibody confirmation.
What this interaction means in plain words
Hepatitis A vaccine inactivated and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hepatitis A vaccine inactivated belongs to Anti Virals; Methotrexate belongs to Oncology.
Why it happens
Methotrexate suppresses lymphocyte proliferation, reducing the humoral response to vaccination.
What to do
Vaccinate before starting methotrexate when possible, and continue therapy otherwise. Consider checking antibody titres in high-risk patients and giving booster doses if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Frequently asked questions
Can I take Hepatitis A vaccine inactivated with Methotrexate?
MediHelp rates the interaction as moderate. Hepatitis A vaccine inactivated and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methotrexate can blunt antibody responses to vaccines, so protection from hepatitis A vaccination may be reduced. The inactivated vaccine is safe to give, but may need attention to timing or antibody confirmation.
How serious is the interaction between Hepatitis A vaccine inactivated and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting methotrexate when possible, and continue therapy otherwise. Consider checking antibody titres in high-risk patients and giving booster doses if response is inadequate.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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