Drug interactions
Hepatitis A vaccine inactivated + Ofatumumab sc
Severity: Moderate
Hepatitis A vaccine inactivated and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells, which can reduce antibody responses to inactivated vaccines such as hepatitis A. Inactivated vaccines pose no infection risk, but protection may be inadequate.
What this interaction means in plain words
Hepatitis A vaccine inactivated and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic: anti-CD20 mediated B-cell depletion reduces vaccine antibody production.
What to do
Give inactivated vaccines at least 2 weeks before starting ofatumumab where possible. If vaccinated during therapy, consider checking antibody titers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Frequently asked questions
Can I take Hepatitis A vaccine inactivated with Ofatumumab sc?
MediHelp rates the interaction as moderate. Hepatitis A vaccine inactivated and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells, which can reduce antibody responses to inactivated vaccines such as hepatitis A. Inactivated vaccines pose no infection risk, but protection may be inadequate.
How serious is the interaction between Hepatitis A vaccine inactivated and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give inactivated vaccines at least 2 weeks before starting ofatumumab where possible. If vaccinated during therapy, consider checking antibody titers.
What other medicines interact with Hepatitis A vaccine inactivated?
MediHelp also lists interactions of Hepatitis A vaccine inactivated with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Hepatitis A vaccine inactivated page.
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