Drug interactions
Hepatitis A vaccine inactivated + Rituximab-hyaluronidase
Severity: Moderate
Hepatitis A vaccine inactivated and Rituximab-hyaluronidase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rituximab depletes B cells, which markedly reduces antibody responses to vaccines for months. Hepatitis A vaccine given during or shortly after therapy may give inadequate protection.
What this interaction means in plain words
Hepatitis A vaccine inactivated and Rituximab-hyaluronidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CD20-mediated B-cell depletion impairs humoral immune responses to vaccine antigens.
What to do
Give hepatitis A vaccine at least 4 weeks before starting rituximab when feasible. If given during or after treatment, check antibody response and revaccinate after B-cell recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Frequently asked questions
Can I take Hepatitis A vaccine inactivated with Rituximab-hyaluronidase?
MediHelp rates the interaction as moderate. Hepatitis A vaccine inactivated and Rituximab-hyaluronidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rituximab depletes B cells, which markedly reduces antibody responses to vaccines for months. Hepatitis A vaccine given during or shortly after therapy may give inadequate protection.
How serious is the interaction between Hepatitis A vaccine inactivated and Rituximab-hyaluronidase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give hepatitis A vaccine at least 4 weeks before starting rituximab when feasible. If given during or after treatment, check antibody response and revaccinate after B-cell recovery.
What other medicines interact with Hepatitis A vaccine inactivated?
MediHelp also lists interactions of Hepatitis A vaccine inactivated with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Hepatitis A vaccine inactivated page.
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