Drug interactions
Hepatitis b vaccine + Hydrocortisone
Severity: Minor
Hepatitis b vaccine and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids may reduce antibody response to hepatitis B vaccine. The vaccine is non-live, so infection risk is not increased.
What this interaction means in plain words
Hepatitis b vaccine and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Corticosteroid immunosuppression reduces vaccine immune response.
What to do
Vaccinate when indicated and check anti-HBs titers after the series if on high-dose steroids, revaccinating if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hepatitis b vaccine with Hydrocortisone?
MediHelp rates the interaction as minor. Hepatitis b vaccine and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic corticosteroids may reduce antibody response to hepatitis B vaccine. The vaccine is non-live, so infection risk is not increased.
How serious is the interaction between Hepatitis b vaccine and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when indicated and check anti-HBs titers after the series if on high-dose steroids, revaccinating if needed.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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