Drug interactions
Human papillomavirus vaccine bivalent + Hydrocortisone
Severity: Minor
Human papillomavirus vaccine bivalent and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids at supraphysiologic doses may reduce the antibody response to inactivated vaccines. Protection may be lower, but the vaccine is not unsafe in this setting.
What this interaction means in plain words
Human papillomavirus vaccine bivalent and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glucocorticoid-induced immunosuppression blunts vaccine-induced immune responses.
What to do
Vaccinate when indicated rather than withholding it; where possible, give the vaccine before starting high-dose corticosteroids or when doses are lowest. Follow the schedule and consider serologic or booster follow-up in heavily immunosuppressed patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Human papillomavirus vaccine bivalent with Hydrocortisone?
MediHelp rates the interaction as minor. Human papillomavirus vaccine bivalent and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids at supraphysiologic doses may reduce the antibody response to inactivated vaccines. Protection may be lower, but the vaccine is not unsafe in this setting.
How serious is the interaction between Human papillomavirus vaccine bivalent and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when indicated rather than withholding it; where possible, give the vaccine before starting high-dose corticosteroids or when doses are lowest. Follow the schedule and consider serologic or booster follow-up in heavily immunosuppressed patients.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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