Drug interactions
Human papillomavirus vaccine quadrivalent + Methotrexate
Severity: Moderate
Human papillomavirus vaccine quadrivalent and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate may reduce the immune response to the quadrivalent HPV vaccine, so protection may be less robust. The vaccine is non-live and can be given to immunosuppressed patients.
What this interaction means in plain words
Human papillomavirus vaccine quadrivalent and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Methotrexate's immunosuppressive and antiproliferative effects impair vaccine-induced B- and T-cell responses.
What to do
Give the vaccine as scheduled rather than withholding it. Where feasible, vaccinate before methotrexate starts or when immunosuppression is lowest.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Human papillomavirus vaccine quadrivalent with Methotrexate?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine quadrivalent and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methotrexate may reduce the immune response to the quadrivalent HPV vaccine, so protection may be less robust. The vaccine is non-live and can be given to immunosuppressed patients.
How serious is the interaction between Human papillomavirus vaccine quadrivalent and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine as scheduled rather than withholding it. Where feasible, vaccinate before methotrexate starts or when immunosuppression is lowest.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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