Drug interactions
Hydrochlorothiazide-olmesartan + Hydrocortisone
Severity: Moderate
Hydrochlorothiazide-olmesartan and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents promote urinary potassium loss, so combined use can cause or worsen hypokalemia. Low potassium raises the risk of arrhythmia and muscle weakness, particularly with prolonged or high-dose steroid therapy.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Additive kaliuresis from thiazide-induced distal sodium delivery and glucocorticoid mineralocorticoid activity.
What to do
Check serum potassium and magnesium periodically and replace potassium as needed; olmesartan partly offsets the loss but does not remove the need for monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Hydrocortisone?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents promote urinary potassium loss, so combined use can cause or worsen hypokalemia. Low potassium raises the risk of arrhythmia and muscle weakness, particularly with prolonged or high-dose steroid therapy.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium periodically and replace potassium as needed; olmesartan partly offsets the loss but does not remove the need for monitoring.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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