Drug interactions
Hydrochlorothiazide-olmesartan + Indacaterol inhaled
Severity: Moderate
Hydrochlorothiazide-olmesartan and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol, a long-acting beta-2 agonist, can lower serum potassium and prolong the QT interval, and hydrochlorothiazide may add to hypokalemia. Hypokalemia increases the risk of arrhythmia.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 mediated cellular potassium uptake and thiazide renal potassium loss.
What to do
Monitor serum potassium, particularly in patients with cardiac disease or other risk factors for hypokalemia. Replace potassium as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol, a long-acting beta-2 agonist, can lower serum potassium and prolong the QT interval, and hydrochlorothiazide may add to hypokalemia. Hypokalemia increases the risk of arrhythmia.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly in patients with cardiac disease or other risk factors for hypokalemia. Replace potassium as required.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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